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What diseases can be treated using stem cells?

Cord blood stem cell transplants have already changed—and saved—thousands of lives around the world. They have already been used to treat more than 75 diseases, including numerous types of malignancies, anemia's, inherited metabolic disorders and deficiencies of the immune system.

Acute Leukemia:

  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myelogenous Leukemia (AML)
  • Acute Biphenotypic Leukemia
  • Acute Undifferentiated Leukemia

Chronic Leukemia:

  • Chronic Myelogenous Leukemia (CML)
  • Chronic Lymphocytic Leukemia (CLL)
  • Juvenile Chronic Myelogenous Leukemia (JCML)
  • Juvenile Myelomonocytic Leukemia (JMML)

Myelodysplastic Syndromes:

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia (myelofibrosis)
  • Polycythemia Vera
  • Essential Thrombocythemia

Lymphoproliferative Disorders:

  • Non-Hodgkin's Lymphoma
  • Hodgkin's Disease

Phagocyte Disorders:

  • Chediak-Higashi Syndrome
  • Chronic Granulomatous Disease
  • Neutrophil Actin Deficiency
  • Reticular Dysgenesis

Inherited Metabolic Disorders:

  • Mucopolysaccharidoses (MPS)
  • Hurler's Syndrome (MPS-IH)
  • Scheie Syndrome (MPS-IS)
  • Hunter's Syndrome (MPS-II)
  • Sanfilippo Syndrome (MPS-III)
  • Morquio Syndrome (MPS-IV)
  • Maroteaux-Lamy Syndrome (MPS-VI)
  • Sly Syndrome, Beta-Glucuronidase Deficiency (MPS-VII)
  • Adrenoleukodystrophy
  • Mucolipidosis II (I-cell Disease)
  • Krabbe Disease
  • Gaucher's Disease
  • Niemann-Pick Disease
  • Wolman Disease
  • Metachromatic Leukodystrophy

Histiocytic Disorders

  • Familial Erythrophagocytic Lymphohistiocytosis
  • Histiocytosis-X
  • Hemophagocytosis

Inherited Erythrocyte Abnormalities

  • Beta Thalassemia Major
  • Sickle Cell Disease

Inherited Immune System Disorders

  • Ataxia-Telangiectasia
  • Kostmann Syndrome
  • Leukocyte Adhesion Deficiency
  • DiGeorge Syndrome
  • Bare Lymphocyte Syndrome
  • Omenn's Syndrome
  • Severe Combined Immunodeficiency (SCID)
  • SCID with Adenosine Deaminase Deficiency
  • Absence of T & B Cells SCID
  • Absence of T Cells, Normal B Cell SCID
  • Common Variable Immunodeficiency
  • Wiskott-Aldrich Syndrome
  • X-Linked Lymphoproliferative Disorder

Other Inherited Disorders

  • Lesch-Nyhan Syndrome
  • Cartilage-Hair Hypoplasia
  • Glanzmann Thrombasthenia
  • Osteopetrosis

Inherited Platelet Abnormalities

  • Amegakaryocytosis / Congenital Thrombocytopenia

Plasma Cell Disorders

  • Multiple Myeloma
  • Plasma Cell Leukemia
  • Waldenstrom's Macroglobulinemia

Other Malignancies

  • Breast Cancer
  • Wing Sarcoma
  • Neuroblastoma
  • Renal Cell Carcinoma

New medical technology may well use these cells to rebuild cardiac tissue, repair damage due to stroke or spinal cord injuries and reverse the effects of such diseases as multiple sclerosis or Parkinson’s. While the research is still in its early stages, the possibilities are extremely promising. And, banking your child’s stem cells increases access to any of these technologies in the future.

Medical professionals have completed substantial research surrounding the usage of cord blood and the hematopietic stem cells contained in the blood, some key milestons include:

Cord Blood stem cell transfusion cures girl’s brain injury

3/16/2012

Thanks to a re-infusion of cord blood stem cells, a little girl has recovered from a critical brain injury

Umbilical Cord Blood Stem Cells: Prime Source for Transplants and Future Regenerative Medicine

12/5/2011

Umbilical Cord Blood Stem Cells: Prime Source for Transplants and Future Regenerative Medicine

Improvement in Cardiac Function following Transplantation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells

11/18/2011

Improvement in Cardiac Function following Transplantation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells

Stem Cell Transplant Success Story: The Kumar Family

11/18/2009

Thanks to a transplant of stem cells from her brother’s umbilical cord blood, eight-year-old Thamirabharuni Kumar is beating thalassemia.

Texas Man Says Stem Cell Treatment Saved His Life

11/17/2009

Texas man reports improvements after autologous stem cell treatment in Thailand for heart failure; more than 200 scientific trials underway in U.S. for stem cell treatments for heart disease.

Increasing the Number of Stem Cells Derived from Umbilical Cord Blood Provides Alternative to Bone Marrow Transplantation in Adults

11/2/2009

Investigational Product Shown to Expand Population of Umbilical Cord Blood Stem Cells for Treatment of Leukemia and Lymphoma

Adult Stem Cells Help Ease Arthritis

8/7/2009

Dr. Max Gomez of WCBS TV reports on a clinic near Denver, Colorado that is using adult stem cells to treat osteo-arthritis of the knee, hip, ankle, and even back pain. Dr. Christopher Centeno and two of his patients discuss the process and their experience.

Fallopian Tubes a Source of Stem Cells

8/7/2009

BBC News reports that researchers in Sao Paulo, Brazil have discovered that fallopian tubes are an abundant source of mesenchymal stem cells. Because fallopian tubes normally are discarded during surgeries such as hysterectomies, they may be good source for non-controversial donor cells for regenerative medicine. In addition, the researchers anticipate that the cells could be useful for understanding and treating fertility problems. The researchers’ findings were published in the Journal of Transitional Medicine.

University of Alabama at Birmingham Creates Stem Cell Institute

8/7/2009

Birmingham Business Journal - Jimmy DeButts reports in article entitled “UAB to Bring Jobs, Research through Stem Cell Institute.” The University of Alabama at Birmingham is building on the success of its existing biotech research facilities to create a Stem Cell Institute.

CWRU Receives 5 Million Dollars from Ohio Third Frontier Commission

7/28/2009

Medical News Today reports that the Center for Stem Cell & Regenerative Medicine has received $5 million in funding from Ohio’s Third Frontier Commission under the Research Commercialization Program. The Ohio Third Frontier is a bipartisan organization whose aim is to promote the state’s technological strengths and help with commercialization of technologies. The funding will help support new and innovative stem cell technologies including two commercial, four emerging and three pilot projects. This funding will be matched by each of the projects to create a $10 million grant benefiting stem cell and regenerative medicine in Ohio. The Center for Stem Cell & Regenerative Medicine (CSCRM) is comprised of Case Western Reserve University (CWRU), Cleveland Clinic (CC), University Hospitals (UH), and Athersys, Inc., a clinical stage biopharmaceutical company. "This funding provides CSCRM the support it needs to continue to aggressively move new technologies from academic

UConn Professor’s Stem Cell Research May Lead to Improved Heart Attack Recovery

7/28/2009

Promising research which may potentially improve a person’s recovery after suffering a heart attack.

Johns Hopkins Students Embed Stem Cells In Sutures To Enhance Healing

7/28/2009

ScienceDaily reports that biomedical engineering students at Johns Hopkins University have demonstrated a way to embed a patient's own adult stem cells in the surgical thread that doctors use to repair serious orthopedic injuries such as ruptured tendons. The goal, the students said, is to enhance healing and reduce the likelihood of re-injury without changing the surgical procedure itself. At the site of the injury, the stem cells are expected to reduce inflammation and release growth factor proteins that speed up healing, enhancing the prospects for a full recovery and reducing the likelihood of re-injury. In collaboration with orthopedic physicians, the team's preliminary experiments in an animal model have yielded promising results. Provided the trials continue to be successful, it is estimated that possible human trials could take place within about five years. “We believe the stem cells will significantly speed up and improve the healing process,” said Ma

Louisville Man is World’s First Cardiac Stem Cell Recipient

7/24/2009

Laura Ungar of the Louisville Courier-Journal reports on one of the world’s first recipients of an infusion of cardiac stem cells as a part of a Phase 1 clinical trial being conducted by a team of University of Louisville physicians at Jewish Hospital.

Study at University of Wisconsin Uses a Stem Cell Treatment for Type 1 Diabetes

7/24/2009

Study aims to learn whether treating newly diagnosed Type 1 diabetics with adult stem cells can either slow or stop the progression of their disease, thereby reducing or even eliminating insulin dependence.

Stem Cell Treatments Effective for Secondary Leukemia in Breast Cancer Survivors

7/16/2009

Researchers from the City of Hope National Medical Center have reported on a study that suggests that there continues to be improvement in the results of stem cell treatments for patients with secondary leukemia and myelodysplasia.

Novel Stem Cell Trial Targets Heart Disease

7/10/2009

The Reporter’s Kathy Whitney reports that Vanderbilt Heart and Vascular Institute recently enrolled its first patient in a Phase II clinical trial using stem cell treatments aimed to reverse damage to the patient's cardiac muscle caused by heart disease.

Stem Cell Industry Expert Praises, Encourages Continued Progress on Legislation to Promote Benefits of Cord Blood

7/6/2009

CEO praises legislative progress to date and encouraging continued momentum for existing bills through the second half of the year.

U.S. Doctors Treat Heart Attack With Man's Own Stem Cells

6/30/2009

Forbes.com reports that American physicians have performed the first procedure in which a patient received injections of his own heart stem cells to repair cardiac muscle damaged by heart attack.

Eastern Virginia Medical School Studies Stem Cell Treatments for Diabetes

6/12/2009

Eastern Virginia Medical School (EVMS) is conducting this double blind study on the effectiveness of a new therapy using adult stem cells to treat type 1 diabetes.

How Does One Mend A Broken Heart?

6/5/2009

Current research indicates that it may be possible to “fix a broken heart.” Adult stem cells may be used to help replace damaged heart muscles, heart tissue, valves and establish new blood vessels to supply them.

Stem Cell Treatment for Stroke Survivors

6/5/2009

There are many treatments and therapies for stroke victims. Today, the most widely used are various medications, often combined with physical and/or speech therapy. In addition to medication and physical therapy, there is promising research on the benefits of stem cell treatments for stroke victims.

Stem Cells Used on Stroke Victim – First in U.S. to be treated with own Cells

5/31/2009

The Houston Chronicle reports that doctors from the University of Texas Medical School have launched the nation's first experimental trial to treat stroke patients with their own stem cells. This new treatment is directed at patients who were not able to receive a tissue plasminogen activator or who did not respond to the treatment, which is reported as the only treatment available now for stroke victims. Neurologist and Professor Sean Savitz reported that the trial's first patient was treated on March 25, 2009 and is doing well. "We're just at the beginning, but this could be an exciting new area of therapeutic intervention for stroke," said the doctor, adding, "It could be the next frontier."

Mary Tyler Moore discusses her support of the Juvenile Diabetes Research Foundation (JDRF)

5/28/2009

Courtney Ann Jackson of Talk Radio News Service reports on actress Mary Tyler Moore’s announcement of an upcoming Juvenile Diabetes Research Foundation event.

Adult Bone Marrow Stem Cells Injected Into Skeletal Muscle Can Repair Heart Tissue

5/28/2009

Science Daily reports that researchers at the University at Buffalo have demonstrated that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue and reverse heart failure. The study, performed on an animal, showed that this non-invasive procedure increased the number of heart cells two-fold and reduced cardiac tissue injury by 60 percent. It also showed an improved function of the left ventricle, the heart’s primary pumping chamber, by 40%, and reduced fibrosis, the hardening of the heart lining that impairs its ability to contract, by 50%. The novel method of delivering mesenchymal stem cells (MSCs) via an intramuscular route is preferable over clinical trials which have focused more often on invasive procedures such as introducing stem cells directly into the heart. These methods carry more risks and can result in harmful scar tissue, arrhythmia, calcification or small vessel blockages. "For these reasons, and because patients with heart failure

Stem Cell Research Seeks to Wean Non-related Transplant Recipients from Anti-rejection Drugs

5/28/2009

Phase I trial investigating the potential use of stem cells to help reduce or eliminate kidney transplant patients’ reliance on anti-rejection medications

New Study Uses Cord Blood to Treat Children with Type 1 Diabetes

4/23/2009

NBC Los Angeles features a new study in which recently diagnosed diabetic children are being treated with stem cells from umbilical cord blood.

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